Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596806 | 0.83 | MAPT (0.51) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL9515163 | 0.82 | STAT3 (0.40) | HTR1AMAPTTDP1ALDH1A1POLB | |
| SCHEMBL9596924 | 0.81 | MAPT (0.67) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| Oxalic Acid SCHEMBL9613886 | 0.79 | MAPT (0.61) | HTR2AMAPTTDP1KMT2AMEN1 | |
| SCHEMBL9513786 | 0.75 | NPC1 (0.48) | HTR1AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9514704 | 0.75 | NPC1 (0.47) | HTR1AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL19134154 | 0.72 | HTR2A (0.68) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL19134209 | 0.72 | HTR2A (0.68) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL7863739 | 0.72 | HTR2A (0.68) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL9517218 | 0.72 | HTR1A (0.42) | HTR2AHTR1AHTR2CSLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250538-A | Treating CNS disorders; antiserotinin agents | NOVO NORDISK A/S (DK) | 1993-10-05 | — | — | US | disclosed |
| EP-0515462-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1992-12-02 | — | — | EP | disclosed |
| US-5126363-A | Central nervous system disorders | NOVO NORDISK A/S (DK) | 1992-06-30 | — | — | US | disclosed |
| WO-1991012252-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-08-22 | — | — | WO | disclosed |