Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513567 | 0.88 | HTR1A (0.46) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9514753 | 0.85 | HTR1A (0.45) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9613775 | 0.82 | HTR2A (0.56) | HTR1AHTR2AHTR2BMAPTMEN1 | |
| SCHEMBL9596652 | 0.81 | HTR1A (0.52) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9280115 | 0.78 | HTR1A (0.52) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL9515127 | 0.78 | LMNA (0.41) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL10554214 | 0.76 | HTR1A (0.70) | HTR1AHTR2A | |
| SCHEMBL9517325 | 0.75 | LMNA (0.41) | HTR1AHTR2AHTR2BHTR2CMAPT | |
| SCHEMBL10554132 | 0.75 | DRD2 (0.59) | HTR1AHTR2AHTR2BHTR2C | |
| SCHEMBL9514280 | 0.71 | HTR1A (0.44) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515462-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1995-05-31 | — | — | EP | claimed |
| EP-0515462-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1995-05-31 | — | — | EP | disclosed |
| US-5250538-A | Treating CNS disorders; antiserotinin agents | NOVO NORDISK A/S (DK) | 1993-10-05 | — | — | US | disclosed |
| US-5126363-A | Central nervous system disorders | NOVO NORDISK A/S (DK) | 1992-06-30 | — | — | US | disclosed |