Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 3/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.47 |
| ▸ | PNP | P00491 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9288448 | 0.80 | XDH (0.60) | XDHGPR84PNP | |
| SCHEMBL10875892 | 0.77 | PNP (0.47) | GPR84PNPKDM4EALDH1A1LMNA | |
| SCHEMBL249648 | 0.73 | XDH (0.66) | XDHGPR84KDM4EALDH1A1LMNA | |
| SCHEMBL912731 | 0.73 | KDM4E (0.51) | PNPKDM4EALDH1A1LMNAGLA | |
| SCHEMBL8535455 | 0.72 | XDH (0.67) | XDHGPR84KDM4EALDH1A1RIPK1 | |
| SCHEMBL4128821 | 0.71 | XDH (0.56) | XDHGPR84BCHETRPC3TRPC4 | |
| SCHEMBL28174099 | 0.70 | XDH (0.62) | XDHGPR84KDM4EALDH1A1LMNA | |
| SCHEMBL5062385 | 0.70 | ALDH1A1 (0.49) | PNPKDM4EALDH1A1LMNAGLA | |
| 8-Aminoguanine SCHEMBL21760 | 0.70 | KDM4E (0.60) | PNPKDM4EALDH1A1LMNAGLA | |
| SCHEMBL7699028 | 0.69 | GPR84 (0.54) | XDHGPR84BCHETRPC3TRPC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476659-A | Killing; particularly lymphocytic leukemia | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1994011003-A1 | CANCEROUS B CELL TREATMENT USING SUBSTITUTED NUCLEOSIDE DERIVATIVES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-05-26 | — | — | WO | disclosed |
| US-4746651-A | ANTIBIOTIC AND ALDOGYCOSIDYL-GUANINE OR ISOXANTHOPTERIN IMMUNE RESPONSE-ENHANCING AGENT | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1988-05-24 | — | — | US | disclosed |