Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.48 |
| ▸ | IDH2 | P48735 | 7/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9298935 | 1.00 | IDH1 (0.48) | IDH1IDH2MAPK1HSP90AA1HRH4 | |
| SCHEMBL9298449 | 0.90 | IDH1 (0.54) | IDH1IDH2MAPK1HSP90AA1HRH4 | |
| Hydrochloric Acid SCHEMBL9298562 | 0.89 | IDH1 (0.53) | IDH1IDH2MAPK1HSP90AA1HRH4 | |
| Maleic Acid SCHEMBL2882692 | 0.76 | POLB (0.42) | MAPK1HSP90AA1HRH4 | |
| Maleic Acid SCHEMBL2880482 | 0.72 | HSD17B10 (0.41) | MAPK1 | |
| Maleic Acid SCHEMBL8579856 | 0.69 | MAPK8 (0.35) | MAPK1 | |
| Fumaric Acid SCHEMBL9052362 | 0.65 | RAB9A (0.43) | FGFR1 | |
| Maleic Acid SCHEMBL9052358 | 0.65 | RAB9A (0.43) | FGFR1 | |
| SCHEMBL9297829 | 0.64 | FGFR4 (0.50) | IDH1FGFR4 | |
| SCHEMBL1844792 | 0.64 | POLB (0.43) | IDH1MAPK1HSP90AA1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305184-B1 | Pyrimidines or their pharmaceutically acceptable salts thereof | MITSUI PHARMACEUTICALS (JP) | 1994-04-27 | — | — | EP | disclosed |
| US-5304555-A | Pyrimidines and pharmaceutically acceptable salts thereof useful in treatment of neurological disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-19 | — | — | US | disclosed |