Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclamic Acid SCHEMBL8563768 | 0.85 | MAPK1 (0.43) | MAPK1MC4RALDH1A1LMNASMN1; SMN2 | |
| Sulfamic Acid Cyclohexyl Ester SCHEMBL9302056 | 0.77 | SSTR5 (0.41) | MC4RALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8565877 | 0.74 | HSD11B1 (0.46) | MAPK1ALDH1A1LMNASMN1; SMN2MAPT | |
| Sulfamic Acid Cyclohexyl Ester SCHEMBL9303861 | 0.73 | SSTR5 (0.43) | MC4RALDH1A1LMNASMN1; SMN2HTT | |
| Sulfamic Acid Cyclohexyl Ester SCHEMBL9303380 | 0.71 | KCNH2 (0.40) | MC4RLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL9303969 | 0.69 | KCNH2 (0.60) | MC4RALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL9537130 | 0.67 | KCNH2 (0.63) | MAPK1MC4RALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14263834 | 0.65 | TNF (0.57) | ALDH1A1LMNASMN1; SMN2HTTMAPT | |
| SCHEMBL4991751 | 0.63 | LMNA (0.45) | ALDH1A1LMNASMN1; SMN2HTTMAPT | |
| SCHEMBL8563059 | 0.63 | HPGD (0.42) | ALDH1A1LMNAHTTMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278165-A | Oxazolyl imidazol[4,5-b]pyridin and pyrimidine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| US-5217980-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-08 | — | — | US | disclosed |
| EP-0539421-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001687-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |