Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamic Acid Cyclohexyl Ester SCHEMBL9302699 | 0.85 | MAPK1 (0.41) | MAPK1MAPTTSHRMEN1KMT2A | |
| Cyclamic Acid SCHEMBL9302048 | 0.78 | KCNH2 (0.41) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8565877 | 0.74 | HSD11B1 (0.46) | MAPK1MAPTGAATSHRMEN1 | |
| Cyclamic Acid SCHEMBL8560203 | 0.74 | KCNH2 (0.43) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8565135 | 0.73 | GPR119 (0.42) | MAPK1MAPTGAASMN1; SMN2MC4R | |
| SCHEMBL9303969 | 0.73 | KCNH2 (0.60) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| Cyclamic Acid SCHEMBL9303369 | 0.72 | KCNH2 (0.40) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9537130 | 0.65 | KCNH2 (0.63) | MAPK1SMN1; SMN2LMNAMC4RNR4A2 | |
| SCHEMBL4991751 | 0.65 | LMNA (0.45) | MAPTTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14263834 | 0.65 | TNF (0.57) | MAPTTSHRSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539421-B1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-23 | — | — | EP | disclosed |
| US-5278165-A | Oxazolyl imidazol[4,5-b]pyridin and pyrimidine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| US-5217980-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-08 | — | — | US | disclosed |
| EP-0539421-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001687-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |