SCHEMBL9304462

SCHEMBL9304462

C1=C(CCN2CCOCC2)c2ccccc2C1

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 12/20 0.50
POLB P06746 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
CNR2 P34972 3/20 0.46
CHRM2 P08172 1/20 0.44
CHRM4 P08173 1/20 0.44
CHRM5 P08912 1/20 0.44
CHRM1 P11229 1/20 0.44
CHRM3 P20309 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9304524 0.93 SIGMAR1 (0.55) CNR1POLBSIGMAR1CHRM2CHRM4
SCHEMBL13297902 0.85 SLC6A3 (0.50) SIGMAR1CHRM2CHRM4CHRM5CHRM1
SCHEMBL11542316 0.84 SIGMAR1 (0.51) SIGMAR1CHRM2CHRM4CHRM5CHRM1
SCHEMBL6212322 0.79 HTR6 (0.43) SIGMAR1
SCHEMBL15591791 0.79 CNR1 (0.53) CNR1POLBSIGMAR1CNR2
SCHEMBL11620971 0.78 SIGMAR1 (0.54) SIGMAR1
SCHEMBL31121639 0.77 HTR6 (0.56) SIGMAR1
SCHEMBL2338975 0.77 HTR6 (0.56) SIGMAR1
SCHEMBL11542289 0.77 SIGMAR1 (0.53) SIGMAR1
SCHEMBL20768130 0.75 CNR1 (0.48) CNR1POLBSIGMAR1CNR2CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024258822-A1 PRECURSORS OF PERIPHERALLY RESTRICTED CANNABINOIDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-12-19 WO disclosed
US-20170240521-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-24 US disclosed
US-20170240521-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-24 US disclosed
US-20170240521-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-24 US disclosed
US-9656981-B2 Peripherally-acting cannabinoid receptor agonists for chronic pain THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-05-23 US disclosed
US-9656981-B2 Peripherally-acting cannabinoid receptor agonists for chronic pain THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-05-23 US disclosed
US-9656981-B2 Peripherally-acting cannabinoid receptor agonists for chronic pain THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-05-23 US disclosed
US-20150239859-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2015-08-27 US disclosed
US-20150239859-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2015-08-27 US disclosed
US-20150239859-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2015-08-27 US disclosed
WO-2014015298-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-01-23 WO disclosed
US-5292736-A Morpholinoalkylindenes as antiglaucoma agents STERLING WINTHROP INC. (US) 1994-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150239859-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN CNR2, CNR1, OPRL1 CNR1 2/4885POLB 2262/4885SIGMAR1 118/4885
US-20170240521-A1 PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN CNR2, CNR1, OPRL1 CNR1 2/4885POLB 2262/4885SIGMAR1 118/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.