Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476524 | 0.86 | SIGMAR1 (0.42) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| SCHEMBL293496 | 0.84 | SIGMAR1 (0.41) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| SCHEMBL234864 | 0.84 | CYP3A4 (0.53) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| SCHEMBL8830047 | 0.82 | SIGMAR1 (0.40) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| Propionic Acid SCHEMBL28208685 | 0.82 | ALDH1A1 (0.37) | CYP3A4SMN1; SMN2SIGMAR1TSHRFDPS | |
| SCHEMBL11026037 | 0.81 | CD44 (0.39) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| SCHEMBL4574904 | 0.81 | TAAR1 (0.40) | TSHRTAAR1ALDH1A1PNMTMAPT | |
| SCHEMBL467666 | 0.79 | CYP3A4 (0.37) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| SCHEMBL23159850 | 0.79 | ALOX15 (0.47) | ALOX15CYP3A4CASP1CASP7SMN1; SMN2 | |
| SCHEMBL293842 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200071310-A1 | N-ARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-03-05 | — | — | US | disclosed |
| CN-1089763-C | Indolyl-pyrrolylidene methyl pyrrole derivatives and process for preparing the same | PHARMACIA & UPJOHN SPA (IT) | 2002-08-28 | — | — | CN | disclosed |
| CN-1222911-A | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1999-07-14 | — | — | CN | disclosed |
| US-5366975-A | Pesticides | THE GENERAL HOSPITAL CORPORATION (US) | 1994-11-22 | — | — | US | disclosed |
| WO-1993000811-A1 | INVERTEBRATE PHENYLETHANOLAMINE TRANSPORTER AND THE USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 1993-01-21 | — | — | WO | disclosed |
| US-4207233-A | Azo dyes containing a thiazole component | BASF AKTIENGESELLSCHAFT (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4112100-A | INCREASING THE ENDOGENOUS PRODUCTION OF PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-4088766-A | PRODUCTION OF PROSTAGLANDINS IN MAMMALS | THE UPJOHN COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4001256-A | PROSTAGLANDIN PRODUCTION IN MAMMALS | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071310-A1 | N-ARYL PYRAZOLES AS NRF2 REGULATORS | NFE2L2, NQO1, KEAP1 | ALOX15 313/4885CYP3A4 106/4885CASP1 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.