Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303821 | 0.93 | PRKCB (0.40) | AXLTYRO3MERTKFYNPDE5A | |
| SCHEMBL8138791 | 0.84 | CSNK2A2 (0.39) | ADORA2ACYP1A2CYP2D6TDP1DPP4 | |
| SCHEMBL9305072 | 0.83 | CSNK2A2 (0.40) | MERTKADORA2ATDP1 | |
| SCHEMBL8134219 | 0.81 | CDC7 (0.41) | MERTKTDP1DPP4 | |
| SCHEMBL9305230 | 0.81 | MAOA (0.36) | AXLBUB1GAAKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL8138778 | 0.81 | TDP1 (0.36) | AXLBUB1GAAKDM4ETSHR | |
| SCHEMBL9306122 | 0.79 | HSD17B10 (0.47) | MERTKALDH1A1KDM4ELMNATSHR | |
| Hydrochloric Acid SCHEMBL8134231 | 0.78 | HSD17B10 (0.46) | MERTKALDH1A1KDM4ELMNATSHR | |
| SCHEMBL9304149 | 0.77 | TDP1 (0.41) | MERTKKDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL9304005 | 0.77 | P2RX7 (0.38) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |