SCHEMBL9305833

SCHEMBL9305833

COS(=O)(=S)c1ccccc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
KDM4E B2RXH2 3/20 0.38
POLB P06746 2/20 0.38
HPGD P15428 1/20 0.38
ESR1 P03372 2/20 0.38
ESR2 Q92731 2/20 0.38
GAA P10253 1/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
ALOX12 P18054 1/20 0.38
HTT P42858 1/20 0.38
RAPGEF4 Q8WZA2 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
TP53 P04637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ATM Q13315 1/20 0.36
HTR6 P50406 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11711549 0.79 MEN1 (0.45) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL8409661 0.79 LMNA (0.38) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL260819 0.78 MEN1 (0.47) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL31244372 0.78 MEN1 (0.47) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL27702804 0.77 MEN1 (0.46) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL10891319 0.76 KEAP1 (0.40) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL9432136 0.74 CA2 (0.49) ALDH1A1KMT2AHPGDKEAP1NFE2L2
SCHEMBL5166438 0.74 MYC (0.41) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL8338643 0.74 CA1 (0.46) ALDH1A1MEN1KMT2AKDM4EESR1
SCHEMBL30131228 0.74 MYC (0.41) ALDH1A1MEN1KMT2AKDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113382981-A Disulfide compounds 尼姆生物科技有限公司 2021-09-10 CN disclosed
US-5296505-A Reacting dithianepropenol with ethynyl-beta-ionol in presence of organomagnesium compound, hydrogenating triple bond, reducing diol with low-valency titanium L'OREAL (FR) 1994-03-22 US disclosed
US-5296611-A Propenals substituted with a dithiane ring and processes for the preparation of these propenals L'OREAL (FR) 1994-03-22 US disclosed