Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308154 | 0.92 | HSD17B10 (0.52) | HPGDHSD17B10TRPM8KDM4EALDH1A1 | |
| SCHEMBL9308313 | 0.88 | CYP2D6 (0.47) | L3MBTL1 | |
| SCHEMBL9307850 | 0.84 | LMNA (0.57) | TSHR | |
| SCHEMBL9306979 | 0.83 | HPGD (0.56) | HPGDHSD17B10TSHR | |
| SCHEMBL9308501 | 0.82 | HPGD (0.47) | HPGDHSD17B10KDM4EALDH1A1TSHR | |
| SCHEMBL9307035 | 0.82 | MAPT (0.44) | HPGDHSD17B10TRPM8ALDH1A1 | |
| SCHEMBL9305774 | 0.82 | NFKB1 (0.57) | TRPM8TSHR | |
| SCHEMBL9308107 | 0.81 | TRPM8 (0.55) | HPGDHSD17B10TRPM8TSHR | |
| SCHEMBL9308959 | 0.80 | CXCR3 (0.48) | HPGDHSD17B10KDM4EALDH1A1TSHR | |
| SCHEMBL2189143 | 0.79 | TRPM8 (0.47) | HPGDHSD17B10TRPM8ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |