Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566880 | 0.89 | MAP2K1 (0.44) | PARP1MEN1KMT2APOLBMAPT | |
| SCHEMBL9566907 | 0.82 | AR (0.41) | PARP1MEN1KMT2AGAAPOLB | |
| SCHEMBL27532886 | 0.80 | KIF11 (0.50) | PARP1GAAMAPTKIF11DAO | |
| SCHEMBL9309057 | 0.78 | PARP1 (0.48) | PARP1MEN1KMT2AGAAPKM | |
| SCHEMBL27410225 | 0.77 | DAO (0.49) | PARP1GAAMAPTKIF11DAO | |
| SCHEMBL17505145 | 0.75 | ALDH1A1 (0.57) | PARP1MEN1KMT2AGAAPKM | |
| SCHEMBL27409224 | 0.75 | KIF11 (0.44) | MEN1KMT2APOLBMAPTKIF11 | |
| SCHEMBL9312351 | 0.74 | DAO (0.44) | MAPTKIF11DAORAB9A | |
| SCHEMBL27388577 | 0.74 | PTGS2 (0.53) | MEN1KMT2AGAAMAPTKIF11 | |
| SCHEMBL27411716 | 0.74 | KIF11 (0.43) | PARP1MAPTKIF11DAORAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | disclosed |
| EP-0561252-A1 | 2-Oxoquinoline derivatives as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |