Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HK2 | P52789 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3572840 | 0.97 | KDM4E (0.41) | ESR2KDM4EALDH1A1ESR1ADORA3 | |
| SCHEMBL5463172 | 0.80 | TAAR1 (0.52) | KDM4EALDH1A1MTORTHPOHSD17B10 | |
| SCHEMBL35864 | 0.78 | HSPA5 (0.43) | CYP3A4CYP2C9MEN1LMNAMAPT | |
| SCHEMBL29368767 | 0.78 | HSPA5 (0.43) | CYP3A4CYP2C9MEN1LMNAMAPT | |
| SCHEMBL366656 | 0.77 | ADAMTS4 (0.52) | ALDH1A1HSD17B10LMNATDP1 | |
| SCHEMBL2510833 | 0.76 | KDM4E (0.42) | ESR2KDM4EALDH1A1ESR1ADORA3 | |
| Hydrochloric Acid SCHEMBL1998632 | 0.75 | ADAMTS4 (0.50) | ALDH1A1HSD17B10LMNATDP1 | |
| Bromide SCHEMBL622788 | 0.75 | ADAMTS4 (0.50) | ALDH1A1HSD17B10LMNATDP1 | |
| SCHEMBL2910001 | 0.75 | PNMT (0.44) | OPRD1HSD17B10 | |
| SCHEMBL2475390 | 0.74 | GABRA1 (0.56) | ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900781-B1 | Phenolic acid amides of hydroxy substituted benzylamines | HAARMANN & REIMER GMBH (DE) | 2002-03-20 | — | — | EP | claimed |
| US-6117365-A | N-(3,4-DIHYDROXYBENZYL)-3,5-DIMETHOXY-4-HYDROXY-E-CINNAMIDE, FOR EXAMPLE; USE AS ANTIOXIDANTS OR AS FREE-RADICAL SCAVENGERS, IN PARTICULAR IN THE COSMETIC OR DERMATOLOGICAL FIELDS, AND IN FOODS | HAARMANN & REIMER GMBH (DE) | 2000-09-12 | — | — | US | claimed |
| EP-0900781-A2 | Phenolic acid amides of hydroxy substituted benzylamines | HAARMANN & REIMER GMBH (DE) | 1999-03-10 | — | — | EP | claimed |
| EP-2625190-B1 | DERIVATIVES OF STEROID BENZYLAMINES, HAVING AN ANTIPARASITIC, ANTIBACTERIAL, ANTIMYCOTIC AND/OR ANTIVIRAL ACTION | UNIV JUSTUS LIEBIG GIESSEN (DE) | 2021-07-14 | — | — | EP | disclosed |
| CN-109310649-B | Dihydrochalcone derivatives affecting inflammatory states | 西姆莱斯有限公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-109310649-A | Influence the dihydrochalcone derivative of inflammatory states | 西姆莱斯有限公司 | 2019-02-05 | — | — | CN | disclosed |
| US-8961943-B2 | O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof | SYMRISE AG (DE) | 2015-02-24 | — | — | US | disclosed |
| EP-2245031-B1 | 6,9-DISUBSTITUTED PURINE DERIVATIVES AND THEIR USE AS COSMETICS AND COSMETIC COMPOSITIONS | INST OF EX BOTANY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2014-02-26 | — | — | EP | disclosed |
| US-8575182-B2 | 6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions | Institute of Experimental Botany, Academy of Sciences of the Czeck Republic (CZ) | 2013-11-05 | — | — | US | disclosed |
| US-20130177510-A1 | O/W-EMULSIFIERS, O/W-EMULSIONS AND METHODS OF MANUFACTURE THEREOF | SYMRISE AG (DE) | 2013-07-11 | — | — | US | disclosed |
| US-8454941-B2 | O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof | SYMRISE AG (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20030171617-A1 | 3,4-Dihydroxymandelic acid alkylamides and use thereof | HAARMANN & REIMER GMBH (DE) | 2003-09-11 | — | — | US | disclosed |
| US-20030139470-A1 | 3,4-dihydroxybenzyl-substituted carbonic acid derivatives and the use thereof as antioxidants | HAARMANN & REIMER GMBH (DE) | 2003-07-24 | — | — | US | disclosed |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | HAARMANN & REIMER GMBH (DE) | 2003-04-17 | — | — | US | disclosed |
| US-20030069307-A1 | 2-(3,4-Dihydroxyphenyl)ethyl-substituted carbonic acid derivatives and their use | HAARMANN & REIMER GMBH (DE) | 2003-04-10 | — | — | US | disclosed |
| US-20030053967-A1 | Use of 3,4-dihydroxy-mandelic acid for protecting against oxidative damage caused by ultra-violet light | HAARMANN & REIMER GMBH (DE) | 2003-03-20 | — | — | US | disclosed |
| US-20030049287-A1 | Catechol oximes and their use in cosmetic and dermatological preparations | HAARMANN & REIMER GMBH (DE) | 2003-03-13 | — | — | US | disclosed |
| EP-0900781-B1 | Phenolic acid amides of hydroxy substituted benzylamines | HAARMANN & REIMER GMBH (DE) | 2002-03-20 | — | — | EP | disclosed |
| US-6117365-A | N-(3,4-DIHYDROXYBENZYL)-3,5-DIMETHOXY-4-HYDROXY-E-CINNAMIDE, FOR EXAMPLE; USE AS ANTIOXIDANTS OR AS FREE-RADICAL SCAVENGERS, IN PARTICULAR IN THE COSMETIC OR DERMATOLOGICAL FIELDS, AND IN FOODS | HAARMANN & REIMER GMBH (DE) | 2000-09-12 | — | — | US | disclosed |
| EP-0900781-A2 | Phenolic acid amides of hydroxy substituted benzylamines | HAARMANN & REIMER GMBH (DE) | 1999-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069307-A1 | 2-(3,4-Dihydroxyphenyl)ethyl-substituted carbonic acid derivatives and their use | NFE2L2, AGER, ME2 | ESR2 88/4885KDM4E 789/4885ALDH1A1 253/4885 |
| US-20030171617-A1 | 3,4-Dihydroxymandelic acid alkylamides and use thereof | HNMT, HTR2A, HTR2C | ESR2 3665/4885KDM4E 1863/4885ALDH1A1 84/4885 |
| US-20030049287-A1 | Catechol oximes and their use in cosmetic and dermatological preparations | TYR, LPO, COMT | ESR2 1285/4885KDM4E 543/4885ALDH1A1 127/4885 |
| US-20030139470-A1 | 3,4-dihydroxybenzyl-substituted carbonic acid derivatives and the use thereof as antioxidants | TYR, HAAO, TH | ESR2 1645/4885KDM4E 186/4885ALDH1A1 162/4885 |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | TYR, MITF, HDAC1 | ESR2 4526/4885KDM4E 2169/4885ALDH1A1 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.