Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22167182 | 0.90 | MGLL (0.54) | MGLLMAPTMEN1KMT2AALDH1A1 | |
| Acitazanolast SCHEMBL342549 | 0.89 | GPR35 (0.54) | MGLLMAPTMMP2MMP9COMT | |
| Acitazanolast SCHEMBL3116621 | 0.87 | GPR35 (0.53) | MGLLMAPTMMP2MMP9COMT | |
| SCHEMBL6694019 | 0.87 | MAPT (0.59) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL9573406 | 0.87 | MAPT (0.43) | MGLLMAPTMMP2MMP9COMT | |
| SCHEMBL31680549 | 0.84 | MMP2 (0.54) | MAPTMMP2MMP9COMTMMP8 | |
| SCHEMBL950001 | 0.83 | CYP3A4 (0.60) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9315202 | 0.81 | HPSE (0.40) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL4532779 | 0.81 | KDM4E (0.53) | MGLLMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23796628 | 0.81 | LMNA (0.41) | MAPTMMP2MMP9COMTMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374643-A | Aryl urea (thiourea) and cyanoguanidine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0587180-A2 | Aryl urea (Thiourea) and cyanoguanidine derivatives | E.R. SQUIBB & SONS, INC. (US) | 1994-03-16 | — | — | EP | disclosed |