SCHEMBL9317849

SCHEMBL9317849

C=CC(=O)OCCCCCCN(C)c1ccc(/C=C/c2ccc(S(C)(=O)=O)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 1/20 0.41
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
HPGD P15428 1/20 0.36
ABCB1 P08183 2/20 0.35
ABCC1 P33527 2/20 0.35
ABCG2 Q9UNQ0 2/20 0.35
MAOB P27338 2/20 0.34
TGM2 P21980 1/20 0.34
MAOA P21397 1/20 0.34
APP P05067 3/20 0.34
GSR P00390 1/20 0.34
BCHE P06276 2/20 0.34
ACHE P22303 2/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9317854 1.00 TSHR (0.41) TSHRALDH1A1CYP3A4LMNASMN1; SMN2
SCHEMBL9810749 0.89 MEN1 (0.35) MEN1KMT2AMAOBTGM2MAOA
SCHEMBL9317451 0.89 ALDH1A1 (0.39) TSHRALDH1A1CYP3A4LMNASMN1; SMN2
SCHEMBL9317458 0.89 ALDH1A1 (0.39) TSHRALDH1A1CYP3A4LMNASMN1; SMN2
SCHEMBL9317768 0.88 MMP14 (0.41) TSHRALDH1A1CYP3A4LMNASMN1; SMN2
SCHEMBL9317777 0.88 MMP14 (0.41) TSHRALDH1A1CYP3A4LMNASMN1; SMN2
SCHEMBL9318568 0.86 POLB (0.40) TSHRLMNASMN1; SMN2MEN1KMT2A
SCHEMBL9318562 0.86 POLB (0.40) TSHRLMNASMN1; SMN2MEN1KMT2A
SCHEMBL9318756 0.83 THRB (0.47) TSHRALDH1A1CYP3A4HPGDABCG2
SCHEMBL9317409 0.81 TSHR (0.42) TSHRALDH1A1CYP3A4LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5322986-A Methods for preparing polymer stripe waveguides and polymer stripe waveguides prepared thereby EASTMAN KODAK COMPANY (US) 1994-06-21 US disclosed
EP-0313477-B1 AN OPTICAL ARTICLE CONTAINING A LINEAR POLYMER EXHIBITING A HIGH LEVEL OF SECOND ORDER POLARIZATION SUSCEPTIBILITY EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1993-05-05 EP disclosed
EP-0313474-B1 AN OPTICAL ARTICLE EXHIBITING A HIGH LEVEL OF SECOND ORDER POLARIZATION SUSCEPTIBILITY EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1992-12-23 EP disclosed
US-5157541-A Support with dielectric, reflection metal, polymeric electrooptical layers, couterelectrode EASTMAN KODAK COMPANY (US) 1992-10-20 US disclosed
US-5075043-A Liquid crystals EASTMAN KODAK COMPANY (US) 1991-12-24 US disclosed
US-5075796-A OPTICAL ARTICLE FOR MULTICOLOR IMAGING EASTMAN KODAK COMPANY (US) 1991-12-24 US disclosed
EP-0422725-A2 High x(2) optical article EASTMAN KODAK COMPANY (US) 1991-04-17 EP disclosed
EP-0422723-A2 Optical article for reflection modulation EASTMAN KODAK COMPANY (US) 1991-04-17 EP disclosed
US-4948225-A REFLECTIVE METAL LAYER, DIELECTRICS, PROTECTIVE COATING EASTMAN KODAK COMPANY (US) 1990-08-14 US disclosed
EP-0370922-A2 An optical article containing a linear condensation polymer exhibiting a high level of second order polarization susceptibility EASTMAN KODAK COMPANY (US) 1990-05-30 EP disclosed
US-4900127-A Optical article containing a linear polymer exhibiting a high level of second order polymerization susceptibility EASTMAN KODAK COMPANY (US) 1990-02-13 US disclosed
EP-0313474-A2 An optical article exhibiting a high level of second order polarization susceptibility EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-04-26 EP disclosed
US-4792208-A POLAR ALIGNED NONCENTROSYMMETRIC MOLECULAR DIPOLES; SULFONYL MOIETY AS ELECTRON ACCEPTOR EASTMAN KODAK COMPANY (US) 1988-12-20 US disclosed