Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ASPH | Q12797 | 2/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 5/20 | 0.46 |
| ▸ | GABRD | O14764 | 5/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.46 |
| ▸ | GABRE | P78334 | 5/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10465494 | 0.88 | GABRA1 (0.52) | KDM4EALDH1A1SMN1; SMN2GABRPGABRD | |
| SCHEMBL3879991 | 0.84 | ALDH1A1 (0.49) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL22675639 | 0.82 | ALDH1A1 (0.44) | KDM4EALDH1A1SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL1644378 | 0.81 | CYP1A2 (0.52) | KDM4EALDH1A1SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL22769843 | 0.80 | KDM4E (0.43) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL31072272 | 0.80 | KDM4E (0.43) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL9319716 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL9319138 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL337915 | 0.79 | TSHR (0.57) | KDM4EALDH1A1SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL7263275 | 0.79 | TSHR (0.57) | KDM4EALDH1A1SMN1; SMN2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281943-B1 | Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AG (DE) | 1994-01-12 | — | — | EP | claimed |