Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.39 |
| ▸ | APP | P05067 | 9/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944533 | 0.74 | — | — | |
| SCHEMBL932487 | 0.64 | BACE1 (0.60) | BACE1BACE2APP | |
| SCHEMBL8524528 | 0.63 | ALDH1A1 (0.42) | — | |
| SCHEMBL6580919 | 0.62 | S100B (0.62) | UTS2R | |
| SCHEMBL19886355 | 0.62 | UTS2R (0.35) | UTS2R | |
| SCHEMBL931680 | 0.60 | PTPN1 (0.31) | — | |
| SCHEMBL931600 | 0.58 | BACE1 (0.55) | BACE1KCNH2BACE2APP | |
| SCHEMBL851567 | 0.58 | CHKA (0.50) | — | |
| SCHEMBL249284 | 0.57 | CRHR1 (0.39) | KCNH2UTS2R | |
| SCHEMBL544100 | 0.57 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |