SCHEMBL9324264

SCHEMBL9324264

[SiH3]O[SiH2]Nc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
ALDH1A1 P00352 7/20 0.39
TDP1 Q9NUW8 4/20 0.39
HSD17B10 Q99714 3/20 0.39
CTSD P07339 1/20 0.39
PTGS2 P35354 2/20 0.38
ALOX12 P18054 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
ALOX15 P16050 1/20 0.38
PTGS1 P23219 1/20 0.38
SLC6A2 P23975 1/20 0.38
MAPK1 P28482 1/20 0.38
HTR2B P41595 1/20 0.38
CYP3A4 P08684 3/20 0.36
IDO1 P14902 2/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
LMNA P02545 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28640906 0.82 TSHR (0.36) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL17046019 0.70
SCHEMBL28464256 0.70 ALDH1A1 (0.38) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL30814267 0.69 ALDH1A1 (0.50) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL17409617 0.69 ALDH1A1 (0.50) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL19973312 0.67 ALDH1A1 (0.44) ALDH1A1HSD17B10ALOX12L3MBTL1ALOX15
SCHEMBL11855123 0.66 ALDH1A1 (0.31) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL19973229 0.65 IDO1 (0.43) ALDH1A1TDP1ALOX12CYP3A4IDO1
SCHEMBL13551147 0.65
SCHEMBL9873344 0.65 ALDH1A1 (0.48) TSHRALDH1A1TDP1HSD17B10CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10703915-B2 Compositions and methods for the deposition of silicon oxide films VERSUM MATERIALS US, LLC (US) 2020-07-07 US disclosed
US-20200040192-A9 Compositions and Methods for the Deposition of Silicon Oxide Films VERSUM MATERIALS US, LLC (US) 2020-02-06 US disclosed
US-20180127592-A1 Compositions and Methods for the Deposition of Silicon Oxide Films VERSUM MATERIALS US, LLC (US) 2018-05-10 US disclosed
US-5286890-A Aromatic amine terminated silicone monomers, oligomers, and polymers therefrom HUGHES AIRCRAFT COMPANY (US) 1994-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180127592-A1 Compositions and Methods for the Deposition of Silicon Oxide Films SEPTIN9, SGMS1, SGMS2 TSHR 4852/4885ALDH1A1 3423/4885TDP1 2493/4885
US-20200040192-A9 Compositions and Methods for the Deposition of Silicon Oxide Films SEPTIN9, SGMS1, SGMS2 TSHR 4852/4885ALDH1A1 3423/4885TDP1 2493/4885
US-10703915-B2 Compositions and methods for the deposition of silicon oxide films SEPTIN9, SGMS1, SGMS2 TSHR 4852/4885ALDH1A1 3423/4885TDP1 2493/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.