Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6711077 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EHTR1DHTR1BLMNA | |
| SCHEMBL9323906 | 0.75 | HTR1A (0.49) | KDM4E | |
| SCHEMBL7255363 | 0.73 | HTR6 (0.58) | KDM4ELMNAPOLBHTR6ALOX15 | |
| SCHEMBL9674614 | 0.73 | HTR1D (0.45) | ALDH1A1KDM4EHTR1DHTR1BGAA | |
| SCHEMBL7957307 | 0.72 | HTR1D (0.51) | HTR1DHTR1BHTR6 | |
| Bromide SCHEMBL9325716 | 0.72 | HTR6 (0.57) | KDM4ELMNAPOLBHTR6ALOX15 | |
| SCHEMBL6042752 | 0.70 | DRD2 (0.63) | KDM4EGAAHTR6HTTMAPT | |
| SCHEMBL7957405 | 0.70 | TNF (0.50) | HTR1DHTR1B | |
| SCHEMBL6847847 | 0.70 | PDK4 (0.69) | HTR6 | |
| SCHEMBL9031902 | 0.68 | HTR1D (0.50) | HTR1DHTR1BGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292761-A | Piperidine, tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-03-08 | — | — | US | disclosed |
| US-5260317-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5240942-A | Hypotensive agents; 5-hydroxytryptamine antagonist | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |