Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9324433 | 0.85 | SIGMAR1 (0.39) | DRD2DRD3MAOBTAAR1SIGMAR1 | |
| SCHEMBL9325771 | 0.84 | KCNH2 (0.50) | DRD2DRD3SIGMAR1MAPTKCNH2 | |
| SCHEMBL9325797 | 0.82 | KDM4E (0.40) | DRD2DRD3KCNH2HTR2AOPRM1 | |
| SCHEMBL9325455 | 0.81 | HTR2A (0.39) | DRD2DRD3MAOBTAAR1SIGMAR1 | |
| SCHEMBL9324412 | 0.81 | TRPM8 (0.35) | DRD2DRD3MAOBTAAR1SIGMAR1 | |
| SCHEMBL9327577 | 0.74 | DRD3 (0.54) | DRD2DRD3MAOBTAAR1MAPT | |
| SCHEMBL9326394 | 0.69 | LTA4H (0.41) | DRD2DRD3MAPTKCNH2HTR2A | |
| SCHEMBL9327633 | 0.69 | KCNH2 (0.50) | SIGMAR1MAPTKCNH2 | |
| SCHEMBL10529828 | 0.68 | HTR2A (0.45) | MAPTKCNH2HTR2A | |
| SCHEMBL9326409 | 0.68 | SIGMAR1 (0.39) | DRD2DRD3MAOBTAAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |