Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327633 | 0.86 | KCNH2 (0.50) | KCNH2MAPTKCNJ1TSHRSIGMAR1 | |
| SCHEMBL9326153 | 0.84 | DRD2 (0.37) | KCNH2MAPTDRD2DRD3SIGMAR1 | |
| SCHEMBL9327453 | 0.83 | KCNH2 (0.55) | KCNH2MAPTDRD2DRD3KCNJ1 | |
| SCHEMBL9324295 | 0.83 | KCNH2 (0.49) | KCNH2MAPTKMT2A | |
| SCHEMBL9325797 | 0.80 | KDM4E (0.40) | KCNH2DRD2DRD3 | |
| SCHEMBL9325778 | 0.77 | KCNH2 (0.67) | KCNH2DRD2DRD3 | |
| SCHEMBL11231897 | 0.75 | KCNH2 (0.52) | KCNH2MAPTKCNJ1TSHRPTGES | |
| SCHEMBL11231455 | 0.72 | KCNH2 (0.63) | KCNH2MAPTKCNJ1TSHRPTGES | |
| SCHEMBL9326502 | 0.72 | SIGMAR1 (0.48) | KCNH2SIGMAR1KMT2A | |
| SCHEMBL10531208 | 0.71 | KCNH2 (0.65) | KCNH2MAPTKCNJ1TSHRPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |