Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735386 | 1.00 | PRKCA (0.46) | PRKCALMNAALDH1A1MAPTPRKCE | |
| SCHEMBL9328130 | 0.92 | PRKCA (0.42) | PRKCALMNAALDH1A1MAPTPRKCE | |
| SCHEMBL9736017 | 0.84 | MAPT (0.47) | PRKCALMNAALDH1A1MAPTPRKCE | |
| SCHEMBL9326714 | 0.84 | LMNA (0.49) | PRKCALMNAALDH1A1MAPTPRKCE | |
| SCHEMBL9327916 | 0.84 | MAPT (0.47) | PRKCALMNAALDH1A1MAPTPRKCE | |
| SCHEMBL9803456 | 0.84 | GLS2 (0.34) | ALDH1A1 | |
| SCHEMBL8985096 | 0.81 | SIGMAR1 (0.34) | LMNAALDH1A1 | |
| SCHEMBL9128899 | 0.80 | LMNA (0.38) | PRKCALMNAALDH1A1MAPTPRKCE | |
| SCHEMBL9326362 | 0.78 | ASAH1 (0.41) | LMNAMAPTELANE | |
| SCHEMBL9735390 | 0.77 | PRKCA (0.32) | PRKCAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |