Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9128899 | 0.84 | LMNA (0.38) | LMNAFAAHMAPTMAPK1ELANE | |
| SCHEMBL9326237 | 0.84 | ASAH1 (0.57) | ASAH1FAAHEPHX2TRPV1 | |
| SCHEMBL9328130 | 0.82 | PRKCA (0.42) | LMNAMAPTMAPK1ELANE | |
| SCHEMBL9326797 | 0.82 | ASAH1 (0.44) | ASAH1FAAHMAPTMAPK1EPHX2 | |
| SCHEMBL9159891 | 0.80 | FAAH (0.35) | FAAHMAPTELANE | |
| SCHEMBL9160196 | 0.80 | FAAH (0.35) | FAAHMAPTELANE | |
| SCHEMBL8985142 | 0.80 | FFAR4 (0.36) | LMNAMAPTMAPK1 | |
| SCHEMBL8985104 | 0.78 | LMNA (0.36) | LMNAMAPTMAPK1ELANE | |
| SCHEMBL9326199 | 0.78 | PRKCA (0.46) | LMNAMAPTELANE | |
| SCHEMBL9735386 | 0.78 | PRKCA (0.46) | LMNAMAPTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5212172-A | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-5081147-A | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-14 | — | — | US | disclosed |