Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | TST | Q16762 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327916 | 1.00 | MAPT (0.47) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL9326199 | 0.84 | PRKCA (0.46) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL9128899 | 0.77 | LMNA (0.38) | MAPTLMNAALDH1A1ELANEPRKCA | |
| SCHEMBL9326714 | 0.77 | LMNA (0.49) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL9326362 | 0.75 | ASAH1 (0.41) | MAPTLMNAELANE | |
| SCHEMBL9744651 | 0.72 | ALDH1A1 (0.32) | MAPTALDH1A1ELANE | |
| SCHEMBL6909304 | 0.72 | ASAH1 (0.56) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL9803456 | 0.71 | GLS2 (0.34) | ALDH1A1 | |
| SCHEMBL11201945 | 0.70 | MAPT (0.71) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL22855717 | 0.70 | MAPT (0.71) | MAPTLMNAKDM4EDUSP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0372941-A2 | Anti-inflammatory 5-hydroxy-2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | disclosed |