SCHEMBL9327546

SCHEMBL9327546

O=C(O)Cc1cccc2c(=O)cc(-c3ccc(F)c(F)c3)oc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 8/20 0.58
CYP1A1 P04798 8/20 0.58
CYP1B1 Q16678 8/20 0.58
CYP2D6 P10635 3/20 0.48
CYP3A4 P08684 2/20 0.47
CYP2C19 P33261 2/20 0.47
STAT6 P42226 1/20 0.47
ABCC1 P33527 2/20 0.44
ABCG2 Q9UNQ0 2/20 0.44
CYSLTR1 Q9Y271 1/20 0.44
PRKDC P78527 2/20 0.44
GLA P06280 1/20 0.44
STING1 Q86WV6 1/20 0.44
XDH P47989 1/20 0.43
CDK1 P06493 1/20 0.42
CCNB1 P14635 1/20 0.42
ABCB1 P08183 2/20 0.42
MCL1 Q07820 1/20 0.41
KDM4E B2RXH2 1/20 0.40
PDE5A O76074 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9328729 0.89 CYP2D6 (0.49) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL9327900 0.88 CYP1A2 (0.56) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL9328614 0.87 CYP1A2 (0.59) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL12835505 0.85 CYP1A2 (0.56) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL9327677 0.85 CYP2D6 (0.53) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL12835292 0.85 CYP2D6 (0.51) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL12835503 0.85 CYP1A2 (0.60) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
Mitoflaxone SCHEMBL106705 0.85 CYP1A2 (0.62) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL7083117 0.84 CYP1A2 (0.59) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4
SCHEMBL9327573 0.84 GLA (0.46) CYP1A2CYP1A1CYP1B1CYP2D6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0454728-B1 FLUORINATED FLAVONE ACETIC ACID UPJOHN CO (US) 1994-03-16 EP claimed
US-5238954-A Antitumor agents THE UPJOHN COMPANY (US) 1993-08-24 US claimed
EP-0454728-A1 FLUORINATED FLAVONE ACETIC ACID. UPJOHN CO (US) 1991-11-06 EP claimed
WO-1990008143-A1 FLUORINATED FLAVONE ACETIC ACID THE UPJOHN COMPANY (US) 1990-07-26 WO claimed
EP-0454728-B1 FLUORINATED FLAVONE ACETIC ACID UPJOHN CO (US) 1994-03-16 EP disclosed
US-5238954-A Antitumor agents THE UPJOHN COMPANY (US) 1993-08-24 US disclosed
EP-0454728-A1 FLUORINATED FLAVONE ACETIC ACID. UPJOHN CO (US) 1991-11-06 EP disclosed
WO-1990008143-A1 FLUORINATED FLAVONE ACETIC ACID THE UPJOHN COMPANY (US) 1990-07-26 WO disclosed