Sugi Predict

Sugi Predict / Compounds / SCHEMBL932926

SCHEMBL932926

SCHEMBL932926

O=C(O)c1conc1C1CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.40
▸ POLB P06746 1/20 0.36
▸ KEAP1 Q14145 1/20 0.35
▸ NFE2L2 Q16236 1/20 0.35
▸ TAS1R3 Q7RTX0 2/20 0.34
▸ TAS1R1 Q7RTX1 2/20 0.34
▸ TAS1R2 Q8TE23 2/20 0.34
▸ KDM5A P29375 1/20 0.33
▸ KDM5B Q9UGL1 1/20 0.33
▸ HCAR2 Q8TDS4 1/20 0.33
▸ CHRNA4 P43681 2/20 0.33
▸ EPHX2 P34913 1/20 0.33
▸ ACMSD Q8TDX5 2/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ KDM4C Q9H3R0 2/20 0.31
▸ DHODH Q02127 1/20 0.31
▸ LDHA P00338 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30281241 0.93 ACMSD (0.40) MAPTTAS1R3TAS1R1TAS1R2KDM5A
SCHEMBL20587999 0.93 ACMSD (0.37) MAPTPOLBTAS1R3TAS1R1TAS1R2
SCHEMBL23990444 0.85 MAPT (0.31) MAPTTAS1R3TAS1R1TAS1R2CHRNA4
SCHEMBL23062875 0.83 TAS1R3 (0.33) MAPTTAS1R3TAS1R1TAS1R2CHRNA4
SCHEMBL22207600 0.81 MAPT (0.32) MAPT
SCHEMBL20305332 0.79 LMNA (0.41) MAPTPOLBTAS1R3TAS1R1TAS1R2
SCHEMBL23068842 0.79 EPHX2 (0.33) TAS1R3TAS1R1TAS1R2CHRNA4EPHX2
SCHEMBL30621073 0.75 KMT2A (0.42) MAPTPOLBTAS1R3TAS1R1TAS1R2
SCHEMBL23068961 0.73 MEN1 (0.31) KMT2A
SCHEMBL23068958 0.73 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4143193-B1 IMIDAZOPYRIMIDINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2026-04-22 — — EP disclosed
US-12559496-B2 Imidazopyrimidines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2026-02-24 — — US disclosed
EP-4665454-A1 IMIDAZOTRIAZINE IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2025-12-24 — — EP disclosed
US-20250346602-A1 LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF DICE ALPHA INC (US) 2025-11-13 — — US disclosed
EP-4143195-B1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2025-05-21 — — EP disclosed
CN-115867348-B Imidazopyrimidines as IL-17 modulators 詹森药业有限公司 2025-05-06 — — CN disclosed
EP-4525987-A1 LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2025-03-26 — — EP disclosed
US-12252491-B2 IL-17A inhibitors ELI LILLY AND COMPANY (US) 2025-03-18 — — US disclosed
CN-112119076-B Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors 默沙东有限责任公司 2025-01-10 — — CN disclosed
US-20240376085-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2024-11-14 — — US disclosed
EP-2456308-A2 PYRIDINE DERIVATIVES FOR CONTROLLING INVERTREBATE PESTS BASF SE (DE) 2012-05-30 — — EP disclosed
CN-102471330-A Pyridazine compounds for controlling invertebrate pests BASF SE 2012-05-23 — — CN disclosed
US-20120122681-A1 Pyridine Derivatives Compounds for Controlling Invertebrate Pests BASF SE (DE) 2012-05-17 — — US disclosed
EP-2451808-A1 PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS BASF SE (DE) 2012-05-16 — — EP disclosed
US-20120110705-A1 Pyridazine Compounds for Controlling Invertebrate Pests BASF SE (DE) 2012-05-03 — — US disclosed
WO-2011009804-A2 PYRIDINE DERIVATIVES COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS BASF SE (DE) 2011-01-27 — — WO disclosed
WO-2011003793-A1 PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS BASF SE (DE) 2011-01-13 — — WO disclosed
EP-1517897-A2 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS Pfizer Products Inc. (US) 2005-03-30 — — EP disclosed
US-20040002524-A1 Benzimidazole compounds and their use as estrogen agonists/antagonists CHESWORTH RICHARD (US) 2004-01-01 — — US disclosed
WO-2004000817-A2 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS PFIZER PRODUCTS INC. (US) 2003-12-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250346602-A1 LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF IL17A, IL15, IL18 MAPT 2292/4885POLB 2245/4885KEAP1 1369/4885
US-20120122681-A1 Pyridine Derivatives Compounds for Controlling Invertebrate Pests PRXL2A, GRIN2A, CNR2 MAPT 4787/4885POLB 3515/4885KEAP1 1053/4885
US-20120110705-A1 Pyridazine Compounds for Controlling Invertebrate Pests CNR2, GRIN2C, GRIN2A MAPT 4683/4885POLB 3406/4885KEAP1 798/4885
US-12252491-B2 IL-17A inhibitors IL17A, IL2, IL15 MAPT 679/4885POLB 1754/4885KEAP1 1098/4885
US-12559496-B2 Imidazopyrimidines as modulators of IL-17 IL17A, IL2, IL23R MAPT 4231/4885POLB 3859/4885KEAP1 1809/4885
US-20040002524-A1 Benzimidazole compounds and their use as estrogen agonists/antagonists ESR1, GPER1, ESR2 MAPT 4041/4885POLB 4313/4885KEAP1 2577/4885
US-20240376085-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 IL17A, IL23R, IL4I1 MAPT 4018/4885POLB 3776/4885KEAP1 3721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.