⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330456 | 0.91 | NLRP3 (0.46) | — | |
| SCHEMBL9333721 | 0.88 | LPAR1 (0.46) | — | |
| SCHEMBL7565089 | 0.87 | LMNA (0.48) | — | |
| SCHEMBL9333016 | 0.83 | NLRP3 (0.46) | — | |
| SCHEMBL9330665 | 0.82 | LMNA (0.43) | — | |
| SCHEMBL9333735 | 0.80 | LPAR1 (0.53) | — | |
| SCHEMBL7080977 | 0.78 | — | — | |
| SCHEMBL9330447 | 0.76 | LPAR1 (0.54) | — | |
| SCHEMBL9330682 | 0.72 | RECQL (0.44) | — | |
| SCHEMBL7108589 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364882-A | Acyloenzyme a: cholesterol acyltransferase inhibitors, anticholesterol | WARNER-LAMBERT COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0556308-A1 | OXYSULFONYL UREA ACAT INHIBITORS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992008692-A1 | OXYSULFONYL UREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |