Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 3/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531311 | 0.81 | PTGS1 (0.35) | P2RY2HCRTR1DYRK1ABACE1PTGS1 | |
| SCHEMBL9527837 | 0.73 | DYRK1A (0.38) | P2RY2HCRTR1DYRK1AUBE2MDCUN1D1 | |
| SCHEMBL9531314 | 0.72 | AHR (0.33) | P2RY2HCRTR1DYRK1ABACE1PDE10A | |
| SCHEMBL9335092 | 0.71 | HSD17B10 (0.43) | HSD17B10DYRK1APTGESALDH1A1MIF | |
| SCHEMBL9335490 | 0.69 | RAB9A (0.50) | HSD17B10HCRTR1DYRK1APTGESALDH1A1 | |
| SCHEMBL9338937 | 0.68 | KAT8 (0.50) | HSD17B10DYRK1APTGESALDH1A1GAA | |
| SCHEMBL9338942 | 0.68 | KAT8 (0.50) | HSD17B10DYRK1APTGESALDH1A1GAA | |
| SCHEMBL9338940 | 0.68 | MAPT (0.42) | HSD17B10DYRK1APTGESGAAMIF | |
| SCHEMBL9335106 | 0.68 | HDAC6 (0.41) | HSD17B10DYRK1APTGESGAACYSLTR1 | |
| SCHEMBL9335088 | 0.68 | HSD17B10 (0.43) | HSD17B10DYRK1APTGESMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |