Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866871 | 0.85 | CYP2C9 (0.43) | HDAC8KMT2AHDAC1HDAC2 | |
| SCHEMBL9864708 | 0.83 | HDAC8 (0.40) | LTA4HNPC1RAB9ATDP1LRRK2 | |
| SCHEMBL9337449 | 0.81 | CA1 (0.47) | LTA4HNPC1RAB9ATDP1LRRK2 | |
| SCHEMBL9337569 | 0.78 | LTA4H (0.54) | LTA4HNPC1RAB9ALRRK2HDAC8 | |
| SCHEMBL9335876 | 0.77 | LTA4H (0.44) | LTA4HNPC1RAB9ALRRK2HDAC8 | |
| SCHEMBL9866700 | 0.75 | ITGB3 (0.38) | HDAC8MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL9335827 | 0.74 | CA1 (0.45) | LTA4HLRRK2HDAC8MEN1KMT2A | |
| SCHEMBL5487724 | 0.72 | CHRNB2 (0.46) | — | |
| SCHEMBL9866032 | 0.72 | CA1 (0.50) | LTA4HNPC1RAB9ATDP1LRRK2 | |
| SCHEMBL21408642 | 0.72 | GFER (0.43) | RAB9AHDAC8MEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372486-B1 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | HOFFMANN LA ROCHE (CH) | 1994-06-01 | — | — | EP | disclosed |
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |