Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9329945 | 0.93 | SSTR4 (0.57) | SSTR4SSTR1 | |
| SCHEMBL9346132 | 0.80 | SSTR4 (0.43) | SSTR4SSTR1 | |
| Fumaric Acid SCHEMBL9348870 | 0.77 | LMNA (0.41) | SSTR4 | |
| SCHEMBL9329974 | 0.76 | SSTR4 (0.52) | SSTR4SSTR1 | |
| Fumaric Acid SCHEMBL9348823 | 0.76 | LMNA (0.40) | — | |
| SCHEMBL9345695 | 0.74 | SSTR4 (0.62) | SSTR4SSTR1 | |
| Fumaric Acid SCHEMBL9348961 | 0.74 | MMP2 (0.38) | — | |
| SCHEMBL9329832 | 0.73 | SSTR4 (0.45) | SSTR4SSTR1 | |
| SCHEMBL9329969 | 0.71 | SSTR4 (0.57) | SSTR4SSTR1 | |
| Fumaric Acid SCHEMBL9795190 | 0.70 | BCHE (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |