Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ARG1 | P05089 | 2/20 | 0.43 |
| ▸ | ARG2 | P78540 | 2/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.42 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | TERT | O14746 | 2/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722623 | 0.89 | ALOX15 (0.57) | ALOX15ARG1ARG2KCNA3PRMT3 | |
| Oxalic Acid SCHEMBL9345679 | 0.89 | ARG1 (0.44) | ARG1ARG2KCNA3CHRM3DPP7 | |
| Hydrochloric Acid SCHEMBL26602150 | 0.87 | ALOX15 (0.55) | ALOX15ARG1ARG2KCNA3PRMT3 | |
| Hydrochloric Acid SCHEMBL5107700 | 0.87 | ALOX15 (0.55) | ALOX15ARG1ARG2KCNA3PRMT3 | |
| Oxalic Acid SCHEMBL9345651 | 0.81 | PRMT3 (0.47) | ALOX15ARG1ARG2PRMT3CARM1 | |
| Oxalic Acid SCHEMBL9349126 | 0.78 | PRMT3 (0.45) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL1077689 | 0.78 | GNAI3 (0.49) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL2297876 | 0.77 | KEAP1 (0.50) | ALOX15ARG1ARG2KCNA3GNAI3 | |
| SCHEMBL3899323 | 0.77 | — | — | |
| SCHEMBL10064189 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |