Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.46 |
| ▸ | CHKA known ✓ | P35790 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL504672 | 0.75 | SMN1; SMN2 (0.57) | CYP2D6CYP2C19ACHEBCHEALDH1A1 | |
| Bromide SCHEMBL571679 | 0.75 | CYP2D6 (0.46) | CYP2D6CYP2C19ACHEBCHEALDH1A1 | |
| Bromide SCHEMBL7496125 | 0.75 | CYP2D6 (0.46) | CYP2D6CYP2C19ACHEBCHEALDH1A1 | |
| Bromide SCHEMBL30982171 | 0.75 | SMN1; SMN2 (0.57) | CYP2D6CYP2C19ACHEBCHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL19468910 | 0.75 | KDM4E (0.43) | ACHEBCHEALDH1A1SMN1; SMN2KDM4E | |
| Bromide SCHEMBL3869612 | 0.74 | NPC1 (0.41) | ACHEBCHEALDH1A1SMN1; SMN2KDM4E | |
| Bromide SCHEMBL11215457 | 0.73 | ALDH1A1 (0.45) | CYP2D6CYP2C19ACHEBCHEALDH1A1 | |
| Bromide SCHEMBL1069897 | 0.73 | ACHE (0.79) | ACHEBCHEALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2469671 | 0.72 | RAB9A (0.53) | CYP2D6CYP2C19ACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL6162141 | 0.72 | CYP2D6 (0.47) | CYP2D6CYP2C19ACHEBCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632009-A | Preparation method of 2-amino-1-phenyl methylpyridine onium bromide | 山东友帮生化科技有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-106632009-A | Preparation method of 2-amino-1-phenyl methylpyridine onium bromide | 山东友帮生化科技有限公司 | 2017-05-10 | — | — | CN | disclosed |
| EP-0427526-B1 | Pyridine derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-07-27 | — | — | EP | disclosed |
| US-5155123-A | Inhibiting gastric juice secretion, analgesics, antiinflammatory agents | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-10-13 | — | — | US | disclosed |
| EP-0427526-A1 | Pyridine derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-05-15 | — | — | EP | disclosed |
| US-3933836-A | Pyridinylidene guanidines | E. R. SQUIBB & SONS, INC. (US) | 1976-01-20 | — | — | US | disclosed |