SCHEMBL935069

SCHEMBL935069

Nc1nccnc1Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 2/20 0.47
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
LTA4H P09960 1/20 0.46
MAPK14 Q16539 1/20 0.46
MAPKAPK2 P49137 1/20 0.45
BACE1 P56817 1/20 0.44
CALM1 P0DP23 1/20 0.44
AOC3 Q16853 1/20 0.43
TAAR1 Q96RJ0 1/20 0.41
ALDH1A1 P00352 1/20 0.40
MPO P05164 1/20 0.40
LIMK2 P53671 1/20 0.40
HSD17B10 Q99714 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ROCK1 Q13464 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23440398 0.85 LTB4R (0.41) LTB4RCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8781507 0.84 CALM1 (0.55) LTB4RCYP1A2CYP2D6CYP2C9CALM1
SCHEMBL3170350 0.78 BACE1 (0.47) LTB4RCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8392797 0.76 LTB4R (0.44) LTB4RCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL25383553 0.76 LTB4R (0.44) LTB4RCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL26131691 0.76 ALDH1A1 (0.54) CYP2D6LTA4HTAAR1ALDH1A1
SCHEMBL29999550 0.76 ALDH1A1 (0.54) CYP2D6LTA4HTAAR1ALDH1A1
SCHEMBL12843879 0.75 TP53 (0.46) LTB4RCALM1TAAR1LIMK2
SCHEMBL1571679 0.75 TAAR1 (0.46) LTB4RCYP1A2CYP2D6CYP2C9CALM1
SCHEMBL27462567 0.75 TAAR1 (0.46) LTB4RCYP2D6CALM1TAAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US claimed
US-11939332-B2 Synthesis of coelenterazine INTERNATIONAL PAPER COMPANY (US) 2024-03-26 US claimed
EP-3830088-A1 SYNTHESIS OF COELENTERAZINE International Paper Company (US) 2021-06-09 EP claimed
US-20210070762-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY (US) 2021-03-11 US claimed
CN-112368286-A Synthesis of coelenterazine 国际纸业公司 2021-02-12 CN claimed
JP-2024153780-A Synthesis of coelenterazine インターナショナル・ペーパー・カンパニー 2024-10-29 JP disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US disclosed
EP-4344689-A2 SYNTHESIS OF COELENTERAZINE International Paper Company (US) 2024-04-03 EP disclosed
US-11939332-B2 Synthesis of coelenterazine INTERNATIONAL PAPER COMPANY (US) 2024-03-26 US disclosed
US-11926624-B2 Synthesis of coelenterazine synthesis intermediate INTERNATIONAL PAPER COMPANY (US) 2024-03-12 US disclosed
US-8546147-B2 Imidazo[1,2-α]pyrazin-3(7H)-one derivatives bearing a new electron-rich structure UNIVERSITA DEGLI STUDI DI SIENA (IT) 2013-10-01 US disclosed
US-8546147-B2 Imidazo[1,2-α]pyrazin-3(7H)-one derivatives bearing a new electron-rich structure UNIVERSITA DEGLI STUDI DI SIENA (IT) 2013-10-01 US disclosed
US-20120171703-A1 IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE UNIVERSITÁ DEGLI STUDI DI SIENA (IT) 2012-07-05 US disclosed
US-20120171703-A1 IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE UNIVERSITÁ DEGLI STUDI DI SIENA (IT) 2012-07-05 US disclosed
US-20120171703-A1 IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE UNIVERSITÁ DEGLI STUDI DI SIENA (IT) 2012-07-05 US disclosed
EP-2454261-A1 IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE Universita Degli Studi di Siena (IT) 2012-05-23 EP disclosed
WO-2011007314-A1 IMIDAZO[1,2-α]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE UNIVERSITÀ DEGLI STUDI DI SIENA (IT) 2011-01-20 WO disclosed
WO-2011007314-A1 IMIDAZO[1,2-α]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE UNIVERSITÀ DEGLI STUDI DI SIENA (IT) 2011-01-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11939332-B2 Synthesis of coelenterazine ACHE, UROD, DDT LTB4R 2170/4885CYP1A2 144/4885CYP3A4 527/4885
US-20120171703-A1 IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE GLB1, NDUFV1, IK LTB4R 1693/4885CYP1A2 91/4885CYP3A4 257/4885
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT LTB4R 2170/4885CYP1A2 144/4885CYP3A4 527/4885
US-20210070762-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT LTB4R 2170/4885CYP1A2 144/4885CYP3A4 527/4885
US-11926624-B2 Synthesis of coelenterazine synthesis intermediate DCXR, SI, UROD LTB4R 2049/4885CYP1A2 52/4885CYP3A4 251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.