SCHEMBL936042

SCHEMBL936042

O=P(O)(O)OP(O)(=S)OP(=O)(O)O

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.60
BLM P54132 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
INPP5A Q14642 3/20 0.32
CA4 P22748 1/20 0.32
BTN3A1 O00481 2/20 0.31
INPPL1 O15357 2/20 0.30
SMPD1 P17405 1/20 0.30
INPP5B P32019 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15239278 0.91 FDPS (0.50) FDPSBLMTDP1INPP5A
SCHEMBL6856973 0.88 FDPS (0.47) FDPSBLMTDP1BTN3A1
SCHEMBL11402357 0.86 FDPS (0.45) FDPSBLMTDP1
SCHEMBL13183948 0.82 FDPS (0.41) FDPSBLMTDP1BTN3A1
Pyrophosphoric Acid SCHEMBL28447258 0.81 FDPS (0.77) FDPSBLMTDP1INPP5ACA4
Hydrochloric Acid SCHEMBL7749523 0.80 FDPS (0.45) FDPSBLMTDP1BTN3A1
SCHEMBL333911 0.79
Pyrophosphoric Acid SCHEMBL3654 0.76
Pyrophosphoric Acid SCHEMBL8851914 0.76 FDPS (1.00) FDPSBLMTDP1INPP5ACA4
Pyrophosphoric Acid SCHEMBL292348 0.76 FDPS (1.00) FDPSBLMTDP1INPP5ACA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3938345-B1 CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE NOCION THERAPEUTICS INC (US) 2026-05-06 EP disclosed
US-20260116859-A1 Charged Ion Channel Blockers and Methods for Use NOCION THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20260060989-A1 Charged Ion Channel Blockers And Methods For Use NOCION THERAPEUTICS INC (US) 2026-03-05 US disclosed
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS BROWN DENNIS M (US) 2025-10-09 US disclosed
US-20250270189-A1 Ester Substituted Ion Channel Blockers and Methods for Use NOCION THERAPEUTICS INC (US) 2025-08-28 US disclosed
US-20250263374-A1 Charged Ion Channel Blockers and Methods for Use NOCION THERAPEUTICS INC (US) 2025-08-21 US disclosed
US-20250263375-A1 Charged Ion Channel Blockers and Methods for Use NOCION THERAPEUTICS INC (US) 2025-08-21 US disclosed
US-20250263386-A1 Charged Ion Channel Blockers and Methods for Use NOCION THERAPEUTICS INC (US) 2025-08-21 US disclosed
US-12336993-B2 Therapeutic benefit of suboptimally administered chemical compounds BROWN DENNIS M (US) 2025-06-24 US disclosed
US-12303496-B2 Charged ion channel blockers and methods for use Nocion Therapeutics, Inc. (US) 2025-05-20 US disclosed
EP-0672193-B1 USE OF OLIGONUCLEOTIDES HAVING A CONSERVED G 4 CORE SEQUENCE FOR THE PREPARATION OF A MEDICAMENT ISIS PHARMACEUTICALS INC (US) 2002-08-14 EP disclosed
US-6348312-B1 OLIGONUCLEOTIDE HAVING LENGTH OF 6-100 NUCLEOTIDES, WHEREIN AT LEAST ONE NON-TERMINAL PYRIMIDINE NUCLEOSIDE IS MODIFIED, AND ALSO 5' AND/OR 3' ENDS ARE MODIFIED, BY REPLACEMENT OF 3' AND/OR 5' PHOSPHODIESTER BRIDGE BY PHOSPHOROTHIOATE BRIDGE HOESCHT AKTIENGESELLSCHAFT (DE) 2002-02-19 US disclosed
US-6339068-B1 DETERMINING CPG-N AND CPG-S MOTIFS PRESENT IN NUCLEIC ACID CONSTRUCT COMPRISING AT LEAST ONE CPG-S MOTIF AND NUCLEIC ACID ENCODING ANTIGEN; REMOVING CPG-N MOTIFS FROM NUCLEIC ACID CONSTRUCT; INSERTING CPG-S MOTIFS INTO NUCLEIC ACID CONSTRUCT UNIVERSITY OF IOWA RESEARCH FOUNDATION 2002-01-15 US disclosed
EP-1016715-A1 Oligonucleotides having a conserved G4 core sequence ISIS PHARMACEUTICALS, INC. (US) 2000-07-05 EP disclosed
EP-0942757-A2 RADIOLABELED DNA OLIGONUCLEOTIDE, METHOD OF PREPARATION AND THERAPEUTIC USES THEREOF Angiogene, Inc. (CA) 1999-09-22 EP disclosed
US-5952490-A A CHEMICALLY MODIFIED OLIGONUCLEOTIDE THAT INHIBITS VIRAL ACTIVITY OR PHOSPHOLIPASE A; TREATMENT OF AGING AND MALIGNANT CELL GROWTH ISIS PHARMACEUTICALS, INC. (US) 1999-09-14 US disclosed
US-5821354-A SYNTHESIZING A DNA SEQUENCE IN AT LEAST TWO PARTS; LABELING THE 5' END OF ONE WITH A RADIOISOTOPE; HYBRIDIZING; LIGATING; USEFUL TO PREVENT UNCONTROLLED CELLULAR PROLIFERATION ANGIOGENE INC. (CA) 1998-10-13 US disclosed
WO-1998023299-A2 RADIOLABELED DNA OLIGONUCLEOTIDE, METHOD OF PREPARATION AND THERAPEUTIC USES THEREOF ANGIOGENE INC. (CA) 1998-06-04 WO disclosed
US-5523389-A OLIGONUCLEOTIDE WITH AT LEAST ONE LINKAGE OF PHOSPHOROTHIOATE ISIS PHARMACEUTICALS, INC. (US) 1996-06-04 US disclosed
WO-1992001673-A1 SYNTHESIS AND USES OF SPIN LABELLED RIBONUCLEOSIDES AND RIBONUCLEOTIDES MEDICAL RESEARCH COUNCIL (GB) 1992-02-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS UNG, DPYD, TPMT FDPS 611/4885BLM 1164/4885TDP1 201/4885
US-12303496-B2 Charged ion channel blockers and methods for use TRPV1, ASIC1, TRPA1 FDPS 2654/4885BLM 2975/4885TDP1 4517/4885
US-20250263386-A1 Charged Ion Channel Blockers and Methods for Use TRPV1, TRPV5, TRPV2 FDPS 3336/4885BLM 2856/4885TDP1 3447/4885
US-12336993-B2 Therapeutic benefit of suboptimally administered chemical compounds UNG, DPYD, TPMT FDPS 611/4885BLM 1164/4885TDP1 201/4885
US-20250263375-A1 Charged Ion Channel Blockers and Methods for Use TRPV1, TRPV2, TRPV5 FDPS 3052/4885BLM 3764/4885TDP1 4216/4885
US-20260060989-A1 Charged Ion Channel Blockers And Methods For Use TRPV1, TRPA1, TRPV2 FDPS 4252/4885BLM 3525/4885TDP1 2590/4885
US-20260116859-A1 Charged Ion Channel Blockers and Methods for Use OPRL1, TRPV1, SCN2B FDPS 3621/4885BLM 2298/4885TDP1 4601/4885
US-20250263374-A1 Charged Ion Channel Blockers and Methods for Use TRPV1, TRPV2, TRPV5 FDPS 3052/4885BLM 3764/4885TDP1 4216/4885
US-20250270189-A1 Ester Substituted Ion Channel Blockers and Methods for Use TRPV1, TRPA1, TRPV2 FDPS 1734/4885BLM 4244/4885TDP1 4092/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.