Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.71 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 7/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370835 | 0.90 | LTA4H (0.63) | LTA4HEPHX2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9367030 | 0.87 | MEN1 (0.74) | LTA4HRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL9366570 | 0.87 | RAB9A (0.64) | LTA4HRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL8704595 | 0.86 | USP2 (0.81) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL20211905 | 0.85 | EPHX2 (0.61) | LTA4HEPHX2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6170899 | 0.85 | L3MBTL1 (0.80) | LTA4HRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL12687892 | 0.84 | HDAC6 (0.68) | LTA4HSMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL10054999 | 0.83 | EPHX2 (0.92) | EPHX2RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL1516167 | 0.83 | EPHX2 (1.00) | EPHX2RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL1732806 | 0.83 | ALDH1A1 (0.63) | LTA4HALDH1A1MAPTCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409163-B1 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMA (US) | 1994-12-21 | — | — | EP | disclosed |