Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368019 | 0.92 | DRD4 (0.63) | DRD4SIGMAR1DRD2HTR1AMEN1 | |
| SCHEMBL9373899 | 0.84 | HTR1A (0.51) | DRD4SIGMAR1DRD2HTR1AHTR7 | |
| SCHEMBL9368765 | 0.83 | ADRA1D (0.53) | DRD4SIGMAR1DRD2ADRA1DADRA1A | |
| SCHEMBL9368409 | 0.83 | DRD4 (0.59) | DRD4SIGMAR1DRD2HTR1ADRD3 | |
| SCHEMBL9367716 | 0.82 | LMNA (0.58) | DRD4SIGMAR1DRD2HTR1AHTR7 | |
| SCHEMBL9369539 | 0.82 | DRD4 (0.55) | DRD4SIGMAR1DRD2HTR1ADRD3 | |
| SCHEMBL6999552 | 0.81 | DRD2 (0.58) | DRD4DRD2MEN1KMT2AADRA1B | |
| SCHEMBL9368605 | 0.80 | ADRA1B (0.47) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL9373742 | 0.80 | HTR1A (0.49) | DRD4DRD2HTR1AMEN1KMT2A | |
| SCHEMBL9368508 | 0.77 | HTR1A (0.59) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376607-B1 | Piperazinyl derivatives | LUNDBECK & CO AS H (DK) | 1994-03-02 | — | — | EP | disclosed |
| US-5002948-A | Central Nervous System Disorders | H. LUNDBECK A/S (DK) | 1991-03-26 | — | — | US | disclosed |
| EP-0376607-A1 | Piperazinyl derivatives | H. LUNDBECK A/S (DK) | 1990-07-04 | — | — | EP | disclosed |