Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369539 | 0.93 | DRD4 (0.55) | DRD4DRD2SIGMAR1HTR1AADRA1A | |
| SCHEMBL9368019 | 0.88 | DRD4 (0.63) | DRD4DRD2SIGMAR1HTR1AADRA1A | |
| SCHEMBL9367716 | 0.85 | LMNA (0.58) | DRD4DRD2SIGMAR1HTR1ADRD3 | |
| SCHEMBL9368237 | 0.83 | DRD4 (0.56) | DRD4DRD2SIGMAR1HTR1AADRA1A | |
| SCHEMBL9373899 | 0.79 | HTR1A (0.51) | DRD4DRD2SIGMAR1HTR1AADRA1A | |
| SCHEMBL9368765 | 0.78 | ADRA1D (0.53) | DRD4DRD2SIGMAR1ADRA1AADRA1D | |
| SCHEMBL9368511 | 0.77 | DRD4 (0.69) | DRD4DRD2SIGMAR1HTR1AADRA1A | |
| SCHEMBL27715320 | 0.75 | KCNH2 (0.72) | DRD2SIGMAR1HTR1AADRA1ADRD3 | |
| SCHEMBL7343246 | 0.74 | ADRA1A (0.55) | DRD2HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL9373232 | 0.74 | DRD2 (0.56) | DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376607-B1 | Piperazinyl derivatives | LUNDBECK & CO AS H (DK) | 1994-03-02 | — | — | EP | disclosed |
| US-5002948-A | Central Nervous System Disorders | H. LUNDBECK A/S (DK) | 1991-03-26 | — | — | US | disclosed |
| EP-0376607-A1 | Piperazinyl derivatives | H. LUNDBECK A/S (DK) | 1990-07-04 | — | — | EP | disclosed |