SCHEMBL937041

SCHEMBL937041

CC(O)CNCCc1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.53
KMT2A Q03164 6/20 0.52
MEN1 O00255 4/20 0.52
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.49
MAPK1 P28482 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
KCNH2 Q12809 1/20 0.48
LMNA P02545 2/20 0.48
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CYP1A2 P05177 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
IDO1 P14902 1/20 0.46
ADRB1 P08588 3/20 0.46
ADRB3 P13945 3/20 0.46
HSD17B10 Q99714 1/20 0.46
POLB P06746 1/20 0.44
ADRB2 P07550 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3770898 0.98 TAAR1 (0.52) TAAR1KMT2AMEN1GAAMAPT
Oxalic Acid SCHEMBL27962739 0.92 GAA (0.51) TAAR1KMT2AMEN1GAAMAPK1
SCHEMBL938702 0.85 TAAR1 (0.57) TAAR1KMT2AMEN1GAAMAPT
SCHEMBL28087397 0.85 TAAR1 (0.57) TAAR1KMT2AMEN1GAAMAPT
SCHEMBL13644447 0.85 TAAR1 (0.57) TAAR1KMT2AMEN1GAAMAPT
SCHEMBL28905170 0.84 TAAR1 (0.52) TAAR1KMT2AMEN1GAAMAPT
Hydrochloric Acid SCHEMBL174859 0.84 TAAR1 (0.55) TAAR1KMT2AMEN1GAAMAPT
SCHEMBL15100338 0.84 KMT2A (0.54) TAAR1KMT2AMEN1GAAMAPT
SCHEMBL28134161 0.84 ADRB2 (0.58) MAPK1KCNH2LMNAKDM4EALDH1A1
Hydrochloric Acid SCHEMBL28087267 0.84 TAAR1 (0.55) TAAR1KMT2AMEN1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115784911-A Synthetic method of 1- [2- (4-chlorophenyl) -ethylamino ] -2-propanol 山东省药学科学院 2023-03-14 CN claimed
CN-112358406-A Preparation method of lorcaserin intermediate 山东省药学科学院 2021-02-12 CN claimed
US-20150210625-A1 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS ARENA PHARMACEUTICALS, INC. 2015-07-30 US claimed
US-8952197-B2 Processes for the preparation of 5-HT2C receptor agonists ARENA PHARMACEUTICALS, INC. (US) 2015-02-10 US claimed
CN-104119236-A Synthesis of Lorcaserin and preparation method of intermediate of Lorcaserin SHANGHAI SCIENPHARM CO LTD 2014-10-29 CN claimed
US-8822727-B2 Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine ARENA PHARMACEUTICALS, INC. (US) 2014-09-02 US claimed
EP-2518053-A1 PROCESS FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE Arena Pharmaceuticals, Inc. (US) 2012-10-31 EP claimed
CN-101466684-B Preparation process of 8-chloro-1-methyl-2, 3,4, 5-tetrahydro-1H-3-benzazepine and related intermediate thereof ARENA PHARM INC 2012-06-20 CN claimed
US-20120142967-A1 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS ARENA PHARMACEUTICALS, INC. 2012-06-07 US claimed
US-8168782-B2 synthesis of lorcaserin ARENA PHARMACEUTICALS, INC. (US) 2012-05-01 US claimed
EP-2443080-A2 PROCESS FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS Arena Pharmaceuticals, Inc. (US) 2012-04-25 EP claimed
JP-2011513402-A 2011-04-28 JP claimed
EP-2288585-A1 PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE Arena Pharmaceuticals, Inc. (US) 2011-03-02 EP claimed
US-20110015438-A1 PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE ARENA PHARMACEUTICALS, INC. 2011-01-20 US claimed
WO-2010148207-A2 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS ARENA PHARMACEUTICALS, INC. (US) 2010-12-23 WO claimed
WO-2009111004-A1 PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE ARENA PHARMACEUTICALS, INC. (US) 2009-09-11 WO claimed
CN-101466684-A Preparation process of 8-chloro-1-methyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine and related intermediate thereof ARENA PHARM INC (US) 2009-06-24 CN claimed
US-20090143576-A1 Processes for the Preparation of 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine and Intermediates Related Thereto ARENA PHARMACEUTICALS, INC. 2009-06-04 US claimed
EP-2001852-A2 PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2008-12-17 EP claimed
WO-2007120517-A2 PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2007-10-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142967-A1 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS HTR2C, HTR3C, HTR5A TAAR1 155/4885KMT2A 652/4885MEN1 2296/4885
US-20090143576-A1 Processes for the Preparation of 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine and Intermediates Related Thereto HTR2C, HTR3C, HTR1A TAAR1 203/4885KMT2A 820/4885MEN1 2190/4885
US-20110015438-A1 PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE HTR2C, HTR3C, HTR3A TAAR1 62/4885KMT2A 704/4885MEN1 3087/4885
US-20150210625-A1 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS HTR2C, HTR3C, HTR5A TAAR1 155/4885KMT2A 652/4885MEN1 2296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.