Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRNP | P04156 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22303101 | 0.77 | RXFP1 (0.52) | MAPTKMT2AKDM4EPOLBPRNP | |
| SCHEMBL9380982 | 0.77 | RXFP1 (0.53) | MAPTKMT2AKDM4EPOLBPRNP | |
| SCHEMBL9379922 | 0.77 | ALOX15 (0.52) | KMT2AKDM4EALOX15USP2ALDH1A1 | |
| SCHEMBL9381350 | 0.73 | ALOX15 (0.55) | MAPTKMT2AKDM4EPOLBMAPK1 | |
| SCHEMBL2116085 | 0.73 | CYP1A2 (0.54) | MAPTKMT2AKDM4EPOLBRXFP1 | |
| SCHEMBL72379 | 0.73 | KDM4E (0.70) | MAPTKMT2AKDM4EPOLBL3MBTL1 | |
| SCHEMBL561686 | 0.73 | KDM4E (0.54) | MAPTKMT2AKDM4EPOLBTSHR | |
| SCHEMBL2467305 | 0.73 | ALDH1A1 (0.65) | MAPTKMT2AKDM4EPOLBL3MBTL1 | |
| SCHEMBL31389316 | 0.73 | KDM4E (0.54) | MAPTKMT2AKDM4EPOLBTSHR | |
| SCHEMBL943064 | 0.72 | ALDH1A1 (0.71) | KDM4EPRNPL3MBTL1RXFP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |