Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.53 |
| ▸ | PRNP | P04156 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HK1 | P19367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379905 | 0.85 | CYP2C9 (0.68) | RXFP1PRNPCYP2C9KDM4EHPGD | |
| SCHEMBL10672389 | 0.82 | CYP2C9 (0.75) | RXFP1PRNPNPSR1MAPK10TSHR | |
| SCHEMBL9379792 | 0.77 | MAPT (0.47) | RXFP1PRNPNPSR1MAPK10TSHR | |
| SCHEMBL10675093 | 0.74 | CYP2C9 (0.71) | TSHRCYP2C9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2117807 | 0.72 | MCL1 (0.52) | RXFP1PRNPNPSR1MAPK10TSHR | |
| SCHEMBL27928660 | 0.72 | ALOX15 (0.58) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL9384536 | 0.71 | ALOX15 (0.62) | HPGDALDH1A1HSD17B10ALOX15MGAM | |
| SCHEMBL9385188 | 0.70 | ALOX15 (0.61) | TSHRALOX15 | |
| SCHEMBL30744791 | 0.70 | ALOX15 (0.61) | RXFP1KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL69125 | 0.70 | KDM4E (0.64) | MAPK1KDM4ETDP1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | claimed |
| CN-1027369-C | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | CN | disclosed |
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| CN-1047292-A | EAA antagonists | MERRELL DOW PHARMA (US) | 1990-11-28 | — | — | CN | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |