Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498054 | 0.84 | ALDH1A1 (0.44) | ALDH1A1HTTRAB9AMAPTMEN1 | |
| SCHEMBL9540982 | 0.81 | MAPT (0.52) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL9387160 | 0.77 | CYP2A6 (0.40) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL8248608 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HTTRAB9AMAPTMEN1 | |
| SCHEMBL9543716 | 0.74 | PKM (0.58) | ALDH1A1HTTRAB9AMAPTMEN1 | |
| SCHEMBL8664733 | 0.74 | ALDH1A1 (0.62) | ALDH1A1HTTMAPTMEN1KMT2A | |
| SCHEMBL8884838 | 0.74 | ALDH1A1 (0.51) | ALDH1A1HTTRAB9AMAPTMEN1 | |
| SCHEMBL28570276 | 0.73 | ALDH1A1 (0.56) | ALDH1A1HTTRAB9AMAPTMEN1 | |
| SCHEMBL2337025 | 0.73 | ALDH1A1 (0.56) | ALDH1A1HTTRAB9AMAPTMEN1 | |
| SCHEMBL10388574 | 0.73 | GSTM2 (0.54) | ALDH1A1HTTRAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393738-B1 | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1994-11-30 | — | — | EP | disclosed |
| US-5272150-A | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-21 | — | — | US | disclosed |
| EP-0393738-A1 | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-24 | — | — | EP | disclosed |