Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9395781 | 0.86 | FGFR1 (0.40) | FGFR1NPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9675803 | 0.85 | FGFR1 (0.45) | FGFR1PLK1SRCKDR | |
| SCHEMBL8504140 | 0.73 | CYP11B1 (0.34) | MAPTLMNATSHRSMN1; SMN2TDP1 | |
| SCHEMBL9395890 | 0.68 | ATP4A (0.39) | NPC1RAB9AMAPTTP53LMNA | |
| SCHEMBL9395895 | 0.66 | ALDH1A1 (0.41) | RAB9AMAPTTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL9694934 | 0.63 | ATP4A (0.31) | — | |
| SCHEMBL636638 | 0.62 | CYP11B1 (0.50) | LMNATSHRSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL9678510 | 0.62 | FGFR1 (0.47) | FGFR1PLK1SRCKDR | |
| SCHEMBL9560914 | 0.62 | TDP1 (0.46) | FGFR1LMNAPKMTSHRSMN1; SMN2 | |
| SCHEMBL10701671 | 0.62 | ACSS2 (0.42) | FGFR1NPC1RAB9ATP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294439-A | Stabilized benzimidazole derivative and composition | NIPPON CHEMIPHAR CO., LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0248634-B1 | STABILIZED BENZIMIDAZOLE DERIVATIVE AND COMPOSITION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |
| EP-0218336-B1 | USE OF BENZYLSULFINYLBENZIMIDAZOLES AS CYTOPROTECTIVE AGENTS FOR THE GASTROINTESTINAL TRACT | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4824856-A | Method of protecting gastrointestinal tract | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0218336-A2 | Use of benzylsulfinylbenzimidazoles as cytoprotective agents for the gastrointestinal tract | NIPPON CHEMIPHAR CO., LTD. (JP) | 1987-04-15 | — | — | EP | disclosed |