SCHEMBL9397276

SCHEMBL9397276

O=S(=O)(c1cccc2ncccc12)N1CCNCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 1.00
NFKB1 P19838 3/20 1.00
TSHR P16473 2/20 1.00
THPO P40225 1/20 1.00
HIF1A Q16665 1/20 1.00
LMNA P02545 3/20 0.97
MAPT P10636 2/20 0.97
BLM P54132 1/20 0.97
ROCK1 Q13464 5/20 0.59
ROCK2 O75116 5/20 0.59
PRKCE Q02156 3/20 0.59
PRKCD Q05655 3/20 0.59
PRKD1 Q15139 3/20 0.59
PRKX P51817 2/20 0.59
CYP1A2 P05177 3/20 0.59
PRKACA P17612 3/20 0.59
PRKACG P22612 3/20 0.59
PRKACB P22694 3/20 0.59
CYP2C19 P33261 2/20 0.59
PRKD3 O94806 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29968116 1.00 CYP3A4 (1.00) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL9398471 0.95 CYP3A4 (0.90) CYP3A4NFKB1TSHRTHPOHIF1A
Hydrochloric Acid SCHEMBL9780257 0.81 LMNA (0.70) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL2712002 0.79 L3MBTL1 (0.71) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL30366611 0.79 CYP3A4 (0.65) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL17962258 0.78 COMT (0.78) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL9397274 0.78 CYP3A4 (0.64) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL2907389 0.78 ROCK2 (0.67) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL2908180 0.78 ROCK2 (0.67) CYP3A4NFKB1TSHRTHPOHIF1A
SCHEMBL2960623 0.78 MEN1 (0.71) CYP3A4NFKB1TSHRTHPOHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024189434-A1 USE OF NADOLOL TO TREAT PULMONARY SYMPTOMS ASSOCIATED WITH INFECTIONS WITH SARS-CoV-2 CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2024-09-19 WO claimed
CN-117999073-A Use of nadolol to treat chronic obstructive pulmonary disease by blocking the inhibitor protein-2 pathway 慢性呼吸道治疗有限公司 2024-05-07 CN claimed
EP-4304717-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY Chronic Airway Therapeutics Limited (AU) 2024-01-17 EP claimed
US-20220313719-A1 METHODS OF TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR SOOCHOW UNIVERSITY (CN) 2022-10-06 US claimed
WO-2022192252-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2022-09-15 WO claimed
US-20190343861-A1 METHOD OF USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR IN PREPARATION OF DRUGS FOR TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS AND FOR INHIBITING AND PROMOTING PLATELET APOPTOSIS SOOCHOW UNIVERSITY (CN) 2019-11-14 US claimed
CN-108339121-A Application of protein kinase A inhibitor in preparation of medicines for treating diseases related to platelet increase 苏州大学 2018-07-31 CN claimed
US-20250017878-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY CHRONIC AIRWAY THERAPEUTICS LTD (AU) 2025-01-16 US disclosed
WO-2024189434-A1 USE OF NADOLOL TO TREAT PULMONARY SYMPTOMS ASSOCIATED WITH INFECTIONS WITH SARS-CoV-2 CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2024-09-19 WO disclosed
CN-117999073-A Use of nadolol to treat chronic obstructive pulmonary disease by blocking the inhibitor protein-2 pathway 慢性呼吸道治疗有限公司 2024-05-07 CN disclosed
EP-4304717-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY Chronic Airway Therapeutics Limited (AU) 2024-01-17 EP disclosed
US-20220313719-A1 METHODS OF TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR SOOCHOW UNIVERSITY (CN) 2022-10-06 US disclosed
US-20190343861-A1 METHOD OF USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR IN PREPARATION OF DRUGS FOR TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS AND FOR INHIBITING AND PROMOTING PLATELET APOPTOSIS SOOCHOW UNIVERSITY (CN) 2019-11-14 US disclosed
CN-108339121-A Application of protein kinase A inhibitor in preparation of medicines for treating diseases related to platelet increase 苏州大学 2018-07-31 CN disclosed
US-5340811-A Bronchodilator agent ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1994-08-23 US disclosed
EP-0471841-A1 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1992-02-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250017878-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY ARRB1, ADRB2, ADRB1 CYP3A4 1354/4885NFKB1 1153/4885TSHR 2692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.