Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400953 | 0.97 | DRD2 (0.49) | DRD2DRD3ADRA1ASIGMAR1SLC6A7 | |
| SCHEMBL25223898 | 0.83 | SIGMAR1 (0.48) | DRD2DRD3SIGMAR1DRD5 | |
| SCHEMBL9401035 | 0.83 | DRD2 (0.50) | DRD2DRD3ADRA1ASIGMAR1SLC6A7 | |
| SCHEMBL9400960 | 0.82 | CYP2D6 (0.54) | DRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL9401064 | 0.79 | DRD2 (0.48) | DRD2DRD3ADRA1AGRIN1GRIN2B | |
| SCHEMBL3209307 | 0.78 | SIGMAR1 (0.71) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL9480933 | 0.78 | HTR1A (0.71) | DRD2DRD3ADRA1AHTR7DRD5 | |
| SCHEMBL9400873 | 0.78 | CYP2D6 (0.59) | DRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL9401046 | 0.76 | ALDH1A1 (0.57) | SIGMAR1SLC6A7 | |
| SCHEMBL9400948 | 0.75 | SLC6A4 (0.52) | DRD2DRD3SIGMAR1HTR7HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| EP-0129128-B1 | 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0129128-A2 | 2-Pyrimidinyl-1-piperazine derivatives, process for their preparation and medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1984-12-27 | — | — | EP | disclosed |