Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.79 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | HPGD | P15428 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9401128 | 0.89 | MTNR1A (0.64) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL1626901 | 0.89 | MTNR1A (1.00) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| Luzindole SCHEMBL4869000 | 0.88 | MTNR1A (1.00) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL9401161 | 0.80 | MTNR1A (0.84) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL28134995 | 0.79 | TDP1 (0.52) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| Luzindole SCHEMBL9118261 | 0.79 | MEN1 (0.81) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL2944735 | 0.78 | MTNR1A (0.66) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL2087168 | 0.77 | HPGD (0.61) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL9751553 | 0.77 | MTNR1A (0.79) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 | |
| SCHEMBL8001497 | 0.76 | MTNR1A (0.63) | MTNR1AMTNR1BTDP1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314908-A | Compounds useful as antiproliferative agents | WHITBY RESEARCH, INC. (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0549916-A2 | Compounds useful as antiproliferative agents | WHITBY RESEARCH, Inc. (US) | 1993-07-07 | — | — | EP | disclosed |
| US-5206377-A | Compounds useful as antiproliferative agents | WHITBY RESEARCH, INC. (US) | 1993-04-27 | — | — | US | disclosed |