Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404276 | 0.82 | PRMT5 (0.34) | NPC1L3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL9404435 | 0.82 | USP30 (0.35) | POLB | |
| SCHEMBL9404358 | 0.81 | PPARA (0.37) | HTTALDH1A1RAB9AMAPTKMT2A | |
| SCHEMBL9404343 | 0.74 | HTT (0.36) | P2RX7HTTNPC1POLBALDH1A1 | |
| SCHEMBL9404510 | 0.74 | P2RX7 (0.44) | P2RX7NPC1RAB9AKMT2ATSHR | |
| Oxalic Acid SCHEMBL9404484 | 0.68 | POLB (0.36) | HTTNPC1L3MBTL1POLBALDH1A1 | |
| Oxalic Acid SCHEMBL9404275 | 0.64 | CHRM2 (0.42) | HTTNPC1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL9404456 | 0.59 | CHRM2 (0.39) | POLBALDH1A1KMT2AKDM4ETSHR | |
| SCHEMBL11671866 | 0.57 | RAB9A (0.52) | P2RX7NPC1L3MBTL1POLBALDH1A1 | |
| SCHEMBL8404086 | 0.54 | CHRM1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |