SCHEMBL941081

SCHEMBL941081

FC(F)(F)c1[c]c(-c2ccccc2)ncn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.36
ASIC3 Q9UHC3 1/20 0.35
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 3/20 0.33
POLB P06746 2/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.32
KMO O15229 1/20 0.32
SCN2A Q99250 3/20 0.32
NPC1 O15118 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ADORA2A P29274 1/20 0.32
MIF P14174 1/20 0.32
HSD17B10 Q99714 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8309365 0.75 CA2 (0.41)
SCHEMBL938615 0.70 SMN1; SMN2 (0.39) ALDH1A1KDM4ETSHRNPC1CYP1A2
SCHEMBL939551 0.66 CA2 (0.34)
SCHEMBL577704 0.63 L3MBTL1 (0.45) KIF11ALDH1A1KDM4EPOLBHPGD
SCHEMBL3645802 0.63 S1PR1 (0.40) KIF11POLBL3MBTL1PTGS1
SCHEMBL4043961 0.60 ATM (0.38) ASIC3ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL434201 0.60 ASIC3 (0.44) ASIC3ALDH1A1NPC1RAB9ASMN1; SMN2
Biphenyl SCHEMBL27729747 0.59 KIF11 (0.50) KIF11ALDH1A1KDM4EHPGDTSHR
SCHEMBL602198 0.57 NOS3 (0.38)
SCHEMBL1886344 0.57 NOS3 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7875606-B2 Herbicides; selectivity between crops and weeds IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2011-01-25 US disclosed
EP-1405853-B1 ISOXAZOLINE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2010-11-03 EP disclosed