Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10396190 | 0.85 | LMNA (0.38) | LMNANPC1RAB9AMAPTNPSR1 | |
| SCHEMBL9418936 | 0.79 | RORC (0.39) | LMNAMAPK1NPC1RAB9AMAPT | |
| SCHEMBL26794304 | 0.78 | ESR1 (0.41) | TDP1 | |
| SCHEMBL9418917 | 0.78 | CA1 (0.36) | LMNAMAPTNPSR1CES2CES1 | |
| SCHEMBL10396191 | 0.75 | NPSR1 (0.37) | LMNAKDM4EMAPTNPSR1CES2 | |
| SCHEMBL2465362 | 0.73 | PGK1 (0.40) | NPSR1L3MBTL1CES2SMN1; SMN2 | |
| SCHEMBL24908565 | 0.70 | ESR1 (0.40) | LMNAKDM4EMAPTNPSR1L3MBTL1 | |
| SCHEMBL7084775 | 0.70 | RORC (0.38) | LMNAMAPK1NPC1RAB9AMAPT | |
| SCHEMBL26794329 | 0.70 | ESR1 (0.32) | LMNAMAPTNPSR1 | |
| SCHEMBL18857468 | 0.69 | CYP19A1 (0.34) | LMNANPC1RAB9AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5319131-A | Reacting dimethyl 2-fluoromalonate with formaldehyde to form hydroxymethylated dimethyl 2-flurormalonate, hydrolysis, decarboxylation, dehydration then esterification with a hexafluoroalkylol | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-07 | — | — | US | disclosed |
| US-5198925-A | α-fluoroacrylic acid esters and polymers thereof | HOECHST AKTIENGESELLSCHAFT | 1993-03-30 | — | — | US | disclosed |
| EP-0203462-B1 | ALPHA-FLUOROACRYLIC-ACID ESTERS AND THEIR POLYMERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0203462-A2 | Alpha-fluoroacrylic-acid esters and their polymers | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-12-03 | — | — | EP | disclosed |