Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
| ▸ | OGG1 | O15527 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10396190 | 0.91 | LMNA (0.38) | LMNAMAPTNPSR1CES2CES1 | |
| SCHEMBL9418936 | 0.85 | RORC (0.39) | LMNAMAPTNPSR1CES2CES1 | |
| SCHEMBL9418908 | 0.78 | PPARD (0.32) | LMNAMAPTNPSR1CES2CES1 | |
| SCHEMBL10396191 | 0.77 | NPSR1 (0.37) | LMNAMAPTNPSR1CES2CES1 | |
| SCHEMBL24908565 | 0.72 | ESR1 (0.40) | LMNAMAPTNPSR1TSHR | |
| SCHEMBL7084775 | 0.72 | RORC (0.38) | LMNAMAPTNPSR1 | |
| SCHEMBL15840364 | 0.71 | SMN1; SMN2 (0.47) | LMNANPSR1 | |
| SCHEMBL21834941 | 0.70 | MAPT (0.40) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL3692621 | 0.70 | ELANE (0.41) | LMNAMAPTNPSR1CES1CYP2D6 | |
| SCHEMBL9575390 | 0.69 | LDHA (0.41) | CA1CA2CA9LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5319131-A | Reacting dimethyl 2-fluoromalonate with formaldehyde to form hydroxymethylated dimethyl 2-flurormalonate, hydrolysis, decarboxylation, dehydration then esterification with a hexafluoroalkylol | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-07 | — | — | US | disclosed |
| US-5198925-A | α-fluoroacrylic acid esters and polymers thereof | HOECHST AKTIENGESELLSCHAFT | 1993-03-30 | — | — | US | disclosed |
| EP-0203462-B1 | ALPHA-FLUOROACRYLIC-ACID ESTERS AND THEIR POLYMERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0203462-A2 | Alpha-fluoroacrylic-acid esters and their polymers | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-12-03 | — | — | EP | disclosed |