Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269889 | 0.96 | PDGFRA (0.49) | PDGFRAMAPK8CDK5CLK4GAA | |
| SCHEMBL9265637 | 0.85 | GSTP1 (0.51) | PDGFRAMAPK8CDK5CLK4GAA | |
| SCHEMBL9455121 | 0.85 | ALDH1A1 (0.46) | GAACYP1A2LMNABRD4KDM4E | |
| SCHEMBL13754678 | 0.82 | HPGDS (0.48) | PDGFRAMAPK8CDK5CLK4GAA | |
| SCHEMBL9269940 | 0.81 | SLC2A1 (0.49) | GAACYP1A2LMNAMAPTBRD4 | |
| SCHEMBL9136486 | 0.81 | IMPDH2 (0.47) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3398595 | 0.81 | LMNA (0.49) | GAACYP1A2LMNAMAPTKDM4E | |
| SCHEMBL9455077 | 0.81 | KEAP1 (0.49) | MAPTKDM4ESMN1; SMN2PTGS2 | |
| SCHEMBL5100169 | 0.80 | SLC2A1 (0.48) | GAACYP1A2LMNAMAPTBRD4 | |
| SCHEMBL9259612 | 0.80 | KEAP1 (0.47) | MAPTKDM4ESMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6199796-A | — | — | None | — | — | JP | disclosed |
| JP-H06199796-A | PYRIDINE DERIVATIVE | IMPERIAL CHEM IND PLC <ICI> | 1994-07-19 | — | — | JP | disclosed |
| US-5198439-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-30 | — | — | US | disclosed |
| US-5130318-A | Hypotensive agents and for treatment of congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-14 | — | — | US | disclosed |
| CN-1055925-A | Pyridine derivate and preparation method thereof | ICI PLC (GB) | 1991-11-06 | — | — | CN | disclosed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | disclosed |